Online ISSN: 1949-2553

Protein modification may help explain how prostate cancer spreads

January 15, 2018
A slight change in a protein can cause prostate cancer cells to become aggressive and invade other parts of the body, a new study found. The research findings, which were published in Oncotarget, provide more insight into the aggressive nature of cancer and could lead to the development of more effective treatments. Migrating cancer cells The spread of cancer, or metastasis, happens when cells break free from the original tumor and relocate to another location through the bloodstream. Cancer that has spread to other sites of the body is harder to control and often deadly. Researchers from Sweden sought to… continue reading »

Gene protein USP11 found to play a role in suppressing DNA damage from cancer causing agents

January 15, 2018
The mechanism called nucleotide excision repair (NER), responsible for protecting our skin and organs from the effects of carcinogens and UV radiation, is poorly understood. In Oncotarget, Volume 8, Issue 57, researchers set out to understand the specific role a gene protein called ubiquitin-specific peptidase 11 (USP11) plays in suppressing DNA damage and the development of tumors. NER is the most versatile DNA repair system for removing various forms of bulky DNA damage induced by environmental carcinogens, including solar ultraviolet B (UVB) radiation and air pollutants. NER has two subtypes based on the location of the damage in DNA. The… continue reading »

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Research strives to improve clear cell ovarian cancer treatment options

January 15, 2018
Ovarian cancer is the most lethal of gynecologic cancers in the United States resulting in 14.000 deaths each year. The majority of ovarian cancer arises from fallopian tube or ovarian surface epithelial cells. Despite major differences in the features, all ovarian cancers are treated with surgery followed by chemotherapy. As described in Oncotarget Issue 8, Volume 57, researchers sought to identify potential therapeutic targets to improve the treatment of clear cell ovarian cancer (CCOC), an epithelial ovarian cancer. There are different many subtypes of these cancers with distinct genetic features, biologic properties and clinical outcomes. Researchers began by narrowing down… continue reading »

Substance in cannabis may improve Glioblastoma treatment

January 15, 2018
Glioblastoma is the most common form of brain cancer in adults, and radiation therapy is standard procedure during treatment. Recent research shows that cannabinoids, a class of chemicals best known because of their presence in cannabis, may be able to enhance the effecti veness of radiotherapy. Researchers at Columbia University recently published a paper in Oncotarget, Volume 8, Issue 43 examining the role of the cannabinoid cannabidiol (CBD) in communication between cells, in particular its potential to increase death of glioblastoma cells in response to radiation therapy—without causing similar cell death in normal brain cells. Treating glioblastoma with radiation and… continue reading »

Overcoming resistance: Researchers search for new therapies for advanced kidney cancer

January 15, 2018
Over the past 10 years, the availability of treatments that use drugs or other substances to identify and attack specific types of cancer cells with less harm to normal cells (targeted therapies) has led to improved response and overall survival of patients suffering from advanced kidney cancer. One of these targeted therapies is a pharmaceutical drug known as a tyrosine kinase inhibitor. Tyrosine kinases are enzymes that are responsible for activating proteins by sending them a signal, called signal transduction. The drug works by blocking the signaling. However, most tumors develop resistance to the therapy and progress. Researchers in Heidelberg,… continue reading »