Online ISSN: 1947-6027

Exploring ways to overcome treatment resistance in lung cancer

February 12, 2018
Some lung cancers develop resistance to treatment, but researchers have recently learned more about a potential mechanism that fuels the cancer growth. These findings may lead to the development of a drug that can interrupt that pathway, according to a study published recently in Genes & Cancer. The most common form of lung cancer, called non-small-cell lung cancer, has been treated with some success with targeted therapies that work by blocking, or inhibiting, the signaling of enzymes that are responsible for activating proteins, called tyrosine kinases. However, the treatment eventually fails when a tumor develops resistance to the tyrosine kinase… continue reading »

Omega-3 fatty acid shows potential as a non-toxic additive to chemotherapy

February 6, 2018
An omega-3 fatty acid, docosahexaenoic acid (DHA), promotes cell death in multiple myeloma (a type of cancer arising from cancerous white blood cells in the bone marrow) and may potentially enhance the effectiveness of chemotherapy, according to research findings published in Genes & Cancer. Multiple myeloma is difficult to treat with drugs because the multiple myeloma cells override the patient’s immune response and hijack other pathways to continue to survive and grow. One of those pathways is called “signal transducer and activator of transcription 3” (STAT3) and is responsible for cell growth and death. Transcription 3 refers to a group… continue reading »

Genes & Cancer


Cancer: The role of mutations in cell-to-cell interactions

February 6, 2018
The study of cell proteins and pathways are important to cancer research. A protein molecule that receives chemical signals from outside a cell is called a protein receptor. A particular protein receptor known as the low-density lipoprotein related protein 6 (LRP6) receptor is shown to be involved in regulating the effects of a group of proteins responsible for cell-to-cell interactions. These types of interactions occur when an embryo is formed and developed. This molecular pathway is called canonical Wnt signaling, and it has been implicated in various diseases including cancer. Wnt Signaling Pathway The Wnt signaling pathway consists of proteins… continue reading »

Uncovering new effective treatments for mesothelioma

February 1, 2018
Researchers may have uncovered a new target for the treatment of the most common form of mesothelioma. In a study published in Genes & Cancer, a team of international researchers report that a factor known for regulating cellular processes such as cell growth and death in many diseases including cancer, called the platelet-derived growth factor receptor beta (PDGFRB), is responsible for driving tumor growth in malignant pleural mesothelioma (MPM). MPM is a cancer of the protective lining of the lung, known as the pleura, and it is caused by inhaling asbestos. Because this type of cancer is resistant to chemotherapy,… continue reading »

Predicting treatment response in endometrial cancer with genetic markers

January 18, 2018
The process by which proteins are made from ribonucleic acid (RNA) molecules is called translation, and is a process that is constantly regulated in different biological way. One way to regulate protein translation is by binding and degrading RNA molecules with small complementary bits of RNA, known as microRNA (miRNA), so that proteins cannot be made. Recent findings have shown that changes in the way miRNAs usually work to regulate translation are associated with a number of human diseases, including cancer. A team of researchers from the University of Oklahoma analyzed the profiles of miRNA in endometrial cancer, a type… continue reading »