Mission
Our mission is to share novel scientific discoveries across all fields of age-related research. We welcome scientists from all disciplines, not only those in traditional gerontology. We aim to spread knowledge of the mechanisms surrounding aging and age-related disease, and ultimately seek to understand how to modulate these pathways to extend healthy life.
Aging | December 22, 2017
Fat (adipose) tissue inflammation has become widely accepted as a major contributor to metabolic dysfunction and disorders. Obesity causes inflammatory changes in a number of organs involved with metabolism, but less is known about the relationship between fat, aging and inflammation. Fat tissue inflammation predisposes a person toward insulin resistance, which can lead to diabetes, among other metabolic diseases. As described in an article Aging Volume 9, Issue 9, researchers hope to better understand what happens at the cellular and molecular level in the fat tissue in aging to identify valuable therapeutic targets for metabolic diseases. Both age-related weight gain… continue reading »
Aging | December 15, 2017
A study led by researchers from Yale, Vanderbilt, Northeastern University, and Meharry Medical College found that a protein important to energy-producing (mitochondrial) activities in the cell, called Fus1, plays a critical role in aging pathways. The results, which suggest that Fus1 protein and Fus1-dependent pathways and processes may represent new tools and targets for anti-aging strategies, were presented in a paper recently published in Aging. The role of mitochondria It is widely accepted that mitochondria play an important role in the way we age. Mitochondria exist within every nucleus-containing cell. They are the cells’ power plant, creating energy for the… continue reading »

Aging

The dangers of the high fat keto diet, especially for men

AgingDecember 15, 2017
A new study discussed in Aging Volume 9 Issue 3 shows that high fat ketogenic diets (keto diets) decrease the lifespan of male, but not female mice. The study, Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice, by Marina P. Antoch, Andrei V. Gudkov and others, presented findings which might make it important for men to be cautious when embarking on a ketogenic diet regimen. What does the animal study on high fat risks mean for humans? When humans age we experience psychological changes such as memory loss and cognitive decline as well as physical… continue reading »
Aging | December 11, 2017
Is aging inevitable? According to researchers, Dr. Andrei Gudkov and colleagues at Everon Biosciences Inc. (Buffalo NY) and the Roswell Park Cancer Institute (Buffalo, NY), perhaps not. They recently found a new target cell to fight against the “disease of aging,” otherwise known as senescence, in mice. The Everon website states “Aging has been traditionally seen as a law of nature, unavoidable fate of any human being. Following ancient wisdom, we at Everon think of aging as a disease that can be treated and eventually cured.” The exciting research could be a giant leap for anti-aging, and has received a… continue reading »
Aging | December 7, 2017
A research paper on Alzheimer’s disease in Aging found that a healthy lifestyle, namely diet, sleep and exercise, play an important role in improving the cognitive state and hippocampal volumetrics and improvements in quantitative neuropsychological testing. It has been suggested that Alzheimer’s disease (AD) is the third leading cause of death in the United States, behind cardiovascular disease and cancer. Approximately 5.4 million people in the United States are affected by AD. According to the Alzheimer’s Association, cost of caring for Alzheimer’s patients in the U.S. was estimated to be $236 billion in 2016. Thus, scientists are looking for new… continue reading »