Online ISSN: 1945-4589

Can having a youthful outlook affect your lifespan?

January 12, 2018
When you ask someone their age, the answer they give is usually based on their chronological age. But age, alone, is a poor predictor of your lifespan. Researchers set out to study whether biomarkers in your DNA could be used to determine your internal cellular age. These DNA biomarkers occur as part of a vital metabolic process in every cell and every organ of the body (methylation-based biomarkers). These are often referred to as “epigenetic age” or “epigenetic clock” because they can be used to predict a person’s age and estimated lifespan. In a recent article in Aging, Volume 8,… continue reading »

Is there a way to predict an age-related disease?

December 22, 2017
You may recall from your early education that chromosomes are DNA molecules within the nuclei of your cells that contain all or part of the genetic material of an organism. They contain the basic instructions for what make you, you. Everyone has 23 pairs of chromosomes, for a total of 46. At the end of each chromosome is a compound structure called a telomere. As described in Aging, Volume 9, Issue 9, researchers looked at telomere length in the DNA of white blood cells and a natural process in the DNA called that can repress transfer of genetic information (DNA… continue reading »

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Research suggests role of gene protein in age-related metabolic disease

December 22, 2017
Fat (adipose) tissue inflammation has become widely accepted as a major contributor to metabolic dysfunction and disorders. Obesity causes inflammatory changes in a number of organs involved with metabolism, but less is known about the relationship between fat, aging and inflammation. Fat tissue inflammation predisposes a person toward insulin resistance, which can lead to diabetes, among other metabolic diseases. As described in an article Aging Volume 9, Issue 9, researchers hope to better understand what happens at the cellular and molecular level in the fat tissue in aging to identify valuable therapeutic targets for metabolic diseases. Both age-related weight gain… continue reading »

Mitochondrial protein draws attention in age-related research

December 15, 2017
A study led by researchers from Yale, Vanderbilt, Northeastern University, and Meharry Medical College found that a protein important to energy-producing (mitochondrial) activities in the cell, called Fus1, plays a critical role in aging pathways. The results, which suggest that Fus1 protein and Fus1-dependent pathways and processes may represent new tools and targets for anti-aging strategies, were presented in a paper recently published in Aging. The role of mitochondria It is widely accepted that mitochondria play an important role in the way we age. Mitochondria exist within every nucleus-containing cell. They are the cells’ power plant, creating energy for the… continue reading »

The dangers of the high fat keto diet, especially for men

December 15, 2017
A new study discussed in Aging Volume 9 Issue 3 shows that high fat ketogenic diets (keto diets) decrease the lifespan of male, but not female mice. The study, Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice, by Marina P. Antoch, Andrei V. Gudkov and others, presented findings which might make it important for men to be cautious when embarking on a ketogenic diet regimen. What does the animal study on high fat risks mean for humans? When humans age we experience psychological changes such as memory loss and cognitive decline as well as physical… continue reading »