Online ISSN: 1945-4589

Human biomarkers database is game-changer for research on aging and mortality

February 12, 2018
Understanding the biomarkers that cause death (mortality) are of great clinical and research interest. These biomarkers enable clinicians to identify high-risk patient groups, provide a forecast of the likely course of a disease or ailment (prognosis) for individual patients, and help healthcare providers decide which treatment options will be most effective. Because the average human lifespan is long, study of these biomarkers can provide real insight into the aging process and play a key role in evaluating potential therapies. As a result of decades of research across hundreds of publications, researchers have created a publicly accessible database called MortalityPredictors.org to… continue reading »

The top 20 chemical compounds leading to cures for age-related disease are identified

February 12, 2018
Old age is the greatest risk factor for many diseases, so the obvious approach to combat disease would be to slow the aging process. But how? The study of diseases one at a time has proven ineffective, as the disease has already taken hold. It seems that a whole body system approach would be more important in understanding age-related decline. This was the imperative of a group of scientists whose work was described in Aging Volume 9, Issue 7 article entitled, “Machine learning for predicting lifespan-extending chemical compounds” in the search for cures for age-related disease. Start with selecting the… continue reading »

Aging

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Researchers are eager to understand the association of two biomarkers with the process of aging

February 6, 2018
Researchers are always eager to understand the processes that cause aging and disease. In one study, researchers tried to understand the role of two common biomarkers in aging. The presence of the tumor suppressor protein called p16Ink4a, together with an enzyme produced by aging cells called β-galactosidase (SAβG), are commonly accepted as biomarkers of aging cells, called senescent cells (SCs). Recent reports attributed the improvement of the healthspan of aged mice to eradication of senescent cells that had these biomarkers. While this association at first seemed to point to the presence of p16Ink4a/SAβG-positive white blood cells in dead tissue of… continue reading »

Why are older people with human immunodeficiency virus more prone to age-related diseases?

February 6, 2018
Groundbreaking new drugs and treatments have impacted older people living with human immunodeficiency virus (PLWH). Thanks to combinations of drugs that are used to keep HIV infections under control, called combination antiretroviral therapy (cART), PLWH live longer because they suffer from fewer random infections and fewer cancers resulting from AIDS. While patients have gained years, their health remains precarious. There has been an increase in the number of age-related conditions these patients suffer, such as coronary artery disease, chronic obstructive pulmonary disease, and non-AIDS-defining cancers. Is there a connection between age and and HIV that causes these diseases to take… continue reading »

Scientists from around the world gather to discuss latest research on human aging

February 6, 2018
The 2nd annual Interventions in Aging Conference, organized by Fusion Conferences and sponsored by the journal Aging, brought hundreds of scientists to Cancun, Mexico to discuss interventional strategies targeting human aging.